Research Publications

IgD+ age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged.

Pathway specific polygenic risk scores identify pathways and patient clusters associated with inflammatory bowel disease risk, severity and treatment response.

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.

IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.

PGE2 Increases Lentiviral Vector Transduction Efficiency of Human HSC.

Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2.

CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent.

Vaccination To Induce Antibodies Blocking the CX3C-CX3CR1 Interaction of Respiratory Syncytial Virus G Protein Reduces Pulmonary Inflammation and Virus Replication in Mice.

The host response and molecular pathogenesis associated with respiratory syncytial virus infection.

RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response.

Differential roles for cytosolic and microsomal Ca2+-independent phospholipase A2 in cell growth and maintenance of phospholipids.

Identification and distribution of endoplasmic reticulum iPLA2.

AlphaFold3 for Structure-Guided Ligand Discovery

A repurposed drug interferes with nucleic acid to inhibit the dual activities of coronavirus nsp13

Current Computational Methods for Protein-Peptide Complex Structure Prediction

Protein–ligand docking in the machine-learning era

Delta machine learning to improve scoring-ranking-screening performances of protein–ligand scoring functions

De novo Design of SARS-CoV-2 Main Protease Inhibitors

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Lin_F9: A Linear Empirical Scoring Function for Protein–Ligand Docking

Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S

Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila

A two-step binding mechanism for the self-binding peptide recognition of target domains

Structural modeling of HLA-B*1502/peptide/carbamazepine/T-cell receptor complex architecture: implication for the molecular mechanism of carbamazepine-induced Stevens-Johnson syndrome

Structural and energetic insights into the intermolecular interaction among human leukocyte antigens, clinical hypersensitive drugs and antigenic peptides

Self-binding peptides: folding or binding?

Mutatomics analysis of the systematic thermostability profile of Bacillus subtilis lipase A

Biomacromolecular quantitative structure–activity relationship (BioQSAR): a proof-of-concept study on the modeling, prediction and interpretation of protein–protein binding affinity

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach

Computational peptidology: a new and promising approach to therapeutic peptide design