WeDaita Science

Research Publications

Peer-reviewed research from our team spanning immunology, genomics, virology, and drug discovery.

  • 1
    IgD+ age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged.
    Kugler-Umana O, Zhang W, Kuang Y, Liang J, Castonguay CH, Tonkonogy SL, Marshak-Rothstein A, Devarajan P, Swain SL.
    Aging Cell 2022 Immunology doi:10.1111/acel.13705
  • 2
    Pathway specific polygenic risk scores identify pathways and patient clusters associated with inflammatory bowel disease risk, severity and treatment response.
    Bodea CA, Macoritto M, Liu Y, Zhang W, Karman J, King EA, Degner JF, Levesque M, Davis JW, Cao S.
    American Journal of Human Genetics (submitted) 2021 Genomics
  • 3
    The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.
    Swain SL, Kugler-Umana O, Kuang Y, Zhang W.
    Cellular Immunology 2017 Immunology
  • 4
    IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.
    Brahmakshatriya V, Kuang Y, Devarajan P, Xia J, Zhang W, Vong AM, Swain SL.
    Journal of Immunology 2017 Immunology
  • 5
    PGE2 Increases Lentiviral Vector Transduction Efficiency of Human HSC.
    Heffner G, Bonner M, Campbell D, Christiansen L, Pierciey FJ, Zhang W, Lewis G, Smurnyy Y, Hamel A, Shah S, Horton H, Ryu B, Goss K, Negre O, Veres G, Horvath C, Finer M, Gregory P.
    Molecular Therapy, Volume 24, S89–S90 2016 Cell Biology
  • 6
    Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2.
    McKinstry KK, Strutt T, Bautista B, Zhang W, Kuang Y, Cooper A, Swain SL.
    Nature Communications 2014 Immunology
  • 7
    CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent.
    Zhang W, Brahmakshatriya V, Swain SL.
    Experimental Gerontology 2014 Immunology
  • 8
    Vaccination To Induce Antibodies Blocking the CX3C-CX3CR1 Interaction of Respiratory Syncytial Virus G Protein Reduces Pulmonary Inflammation and Virus Replication in Mice.
    Zhang W, Choi Y, Haynes LM, Harcourt JL, Anderson LJ, Jones LP, Tripp RA.
    Journal of Virology, 84, 1148–1157 2010 Virology
  • 9
    The host response and molecular pathogenesis associated with respiratory syncytial virus infection.
    Oshansky CM, Zhang W, Moore E, Tripp RA.
    Future Microbiology, 4, 279–297 2009 Virology
  • 10
    RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response.
    Zhang W, Tripp RA.
    Journal of Virology, 82, 12221–12231 2008 Virology
  • 11
    Differential roles for cytosolic and microsomal Ca2+-independent phospholipase A2 in cell growth and maintenance of phospholipids.
    Saavedra G, Zhang W, Peterson B, Cummings BS.
    Journal of Pharmacology and Experimental Therapeutics, 318, 1211–1219 2006 Cell Biology
  • 12
    Identification and distribution of endoplasmic reticulum iPLA2.
    Kinsey GR, Cummings BS, Beckett CS, Saavedra G, Zhang W, McHowat J, Schnellmann RG.
    Biochemical and Biophysical Research Communications, 327, 287–293 2005 Cell Biology